Ethyl imidazo[1,2-a]pyrimidine-2-carboxylate

Ethyl imidazo[1,2-a]pyrimidine-2-carboxylate - Names and Identifiers

Name	Ethyl imidazo[1,2-a]pyrimidine-2-carboxylate
Synonyms	T56 AN DN FNJ CVO2 Ethyl imidazo[1,2-a]pyrimidine-2-carboxylate Ethy imidazol[1,2-a]pyrimidine-2-carboxylate ETHYL IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLATE Ethyl iMidazol[1,2-a]pyriMidine-2-carboxylate Ethyl Imidazo[1,2-A]Pyrimidine-2-Carboxylate(WXC03684) IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER Imidazo[1,2-a]pyrimidine-2-carboxylic acid, ethyl ester
CAS	64951-06-0
InChI	InChI=1/C9H9N3O2/c1-2-14-8(13)7-6-12-5-3-4-10-9(12)11-7/h3-6H,2H2,1H3

Ethyl imidazo[1,2-a]pyrimidine-2-carboxylate - Physico-chemical Properties

Molecular Formula	C9H9N3O2
Molar Mass	191.19
Density	1.33±0.1 g/cm3(Predicted)
Melting Point	170-172°
pKa	1.98±0.30(Predicted)
Storage Condition	2-8°C
Refractive Index	1.629

Ethyl imidazo[1,2-a]pyrimidine-2-carboxylate - Risk and Safety

Hazard Class

IRRITANT

Ethyl imidazo[1,2-a]pyrimidine-2-carboxylate - Introduction

Ethyl imidazo[1,2-a]pyrimidine-2-carboxylate is an organic compound with the chemical formula C9H8N2O2.

Nature:
Ethyl imidazo[1,2-a]pyrimidine-2-carboxylate is a colorless liquid with a fragrance. It has a density of about 1.19g/cm³, a boiling point of about 315°C and a flash point of about 147°C. It can be dissolved in some organic solvents, such as ethanol and dimethyl sulfoxide.

Use:
Ethyl imidazo[1,2-a]pyrimidine-2-carboxylate has a wide range of applications in organic synthesis. It is often used as an intermediate for the synthesis of anticancer drugs and other drugs in the pharmaceutical field. In addition, it can also be used as a synthetic intermediate for organic photoelectric materials, dyes and coatings.

Preparation Method:
Ethyl imidazo[1,2-a]pyrimidine-2-carboxylate is usually prepared by benzene ring substitution and cycliation reaction. Specifically, 2-chloroimidazo [1,2-a]pyrimidine is first reacted with methyl ethyl ketone to produce the corresponding 2-methylimidazo [1,2-a]pyrimidine, and then reacted with cyanide acetonitrile to obtain 2-methylimidazo [1,2-a]pyrimidine-2-carbonitrile, and then the target product Ethyl imidazo[1,2-a]pyrimidine-2-carboxylate is obtained through acid catalysis and hydrolysis reaction.

Safety Information:
Ethyl imidazo[1,2-a]pyrimidine-2-carboxylate is an organic solvent, which is flammable, irritating and allergenic. Contact with skin, eyes or inhalation of its vapors may be harmful to health. In the process of use, should wear protective gloves, protective glasses and protective mask, to avoid inhalation of steam. When storing and handling, keep away from fire and high temperature environment, and keep good ventilation. In case of accidental contact, rinse immediately with plenty of water and seek medical help.

Last Update：2024-04-09 20:52:54